Genomic Science Program
U.S. Department of Energy | Office of Science | Biological and Environmental Research Program

2023 Abstracts

Ghost Imaging in the X-ray Regime


Justin C. Goodrich*1 ([email protected]), Raphael A. Abrahao2, Lonny Berman1, Cinzia DaVia3, Denis Dolzhenko2, Andrei Fluerasu1, Sanjit Karmakar3, Andrei Nomerotski2, Timothy Paape2, Kwangmin Yu2, and Sean McSweeney1


1National Synchrotron Light Source II, and 2Brookhaven National Laboratory, and 3Stony Brook University



The objective of the NSLS-II Quantum Microscope Project is to explore the possibility of reducing the dose of X-rays interacting with biological samples, while enhancing the resolution and contrast of the measurements, by using ghost imaging (GI) technique (Pittman et al. 1995; Shapiro and Boyd 2012). Experiments were performed with 15 keV and 9.6 keV x-ray beams in type-I (quantum) and type- II (classical) GI, respectively.


The poster will report details on the results obtained with type-I GI, where a diamond crystal was used to down convert 15 keV x-rays to correlated photon pairs, which were afterwards detected by a 1.56 ns event-based photon-counting Timepix3 camera with 55 x 55 microns squared pixels (CERN 2023). The Timepix3 camera served at the same time as signal and idler detector and the collection of spatially correlated photon pairs demonstrated the presence of type I phase matching spontaneous parametric down conversion (SPDC).

Furthermore, results will be reported on a type-II GI experiment using speckle patterns generated by a membrane diffuser illuminated by a 9.6 keV X-ray beam. The speckled light was used to periodically illuminate the object following a sample-in/sample-out method. The ghost image of the object was created by the classical correlations between the corresponding produced frames. To our knowledge, this is the first ghost image of a biological sample (E. Cardamomum seed) with a variable transmission profile, highlighting the capability of this technique to image objects beyond binary masks or shadows.


Pittman, B. et al. 1995. “Optical Imaging by Means of Two-Photon Quantum Entanglement.” Physical Review Journals A 52, R3429(R).

Shapiro, J. H., and W. Boyd 2012. “The Physics of Ghost Imaging.” Quantum Information Processing 11, 949–93.

CERN. Timepix3, 2023. European Organization for Nuclear Research. []

Funding Information

DOE-BER, Bioimaging Science Program, grant KP1607020