Genomic Science Program Timeline

• DOE Provides Nearly $30 Million to Jump Start Bioenergy Research Centers. The U.S. Department of Energy (DOE) today announced it has invested nearly $30 million in end-of-fiscal-year (2007) funds to accelerate the start-up of its three new Bioenergy Research Centers, bringing total DOE Bioenergy Research Center investment to over $400 million. (October)
  Press Release
• Energy Department Selects Three Bioenergy Research Centers for $375 Million in Federal Funding. Secretary Samuel W. Bodman announced three new Bioenergy Research Centers intended to accelerate basic research in the development of cellulosic ethanol and other biofuels. (June)
  Press Release
• Energy and Agriculture Departments Provide $8.3 Million in Funding for Biofuels Research. U.S. Energy Secretary Samuel Bodman and Agriculture Secretary Mike Johanns today announced that the Department of Energy and the Department of Agriculture have jointly selected 11 projects for awards totaling $8.3 million for biobased fuels research that will accelerate the development of alternative fuel resources. (June)
  Press Release
• Joint ASCAC-BERAC Report on Modeling and Simulation for GTL, in response to the charge dated February 23, 2007. (February)
  PDF | Charge Letter
• PI Meeting: Joint Genomics: GTL Awardee Workshop V and Metabolic Engineering 2007 and USDA-DOE Plant Feedstock Genomics for Bioenergy Awardee Workshop 2007, North Bethesda, Maryland. (February11–14)
  Overview | Print-quality PDF | Fast-download PDF
• Number of Planned Bioenergy Research Centers Revised (February)
  Press Release

2006

• DOE-USDA Advancing Renewable Energy Conference, St. Louis, Missouri. USDA Secretary Mike Johanns and U.S. DOE Secretary Samuel Bodman announce nearly $17.5 million for 17 biomass research, development and demonstration projects, to help break our nation’s addiction to oil. (October)
  Press Release | Presentation | President Bush Remarks
• First tree genome sequence published; consortium led by DOE Joint Genome Institute. (September)
  Press Release
• USDA and DOE Fund Genomics Projects For Bioenergy Fuels Research. USDA and DOE jointly award nine grants totaling $5.7 million for biobased fuels research that will accelerate the development of alternative fuel resources. (August)
  Press Release
• USDA and DOE Name Biomass Research and Development Technical Advisory Committee Members. (August)
• DOE Issues Call for New Bioenergy Research Centers. (August)
  Press Release | BRC Fact Sheet | White Paper
• Breaking the Biological Barriers to Cellulosic Ethanol: A Joint Research Agenda. A Research Roadmap Resulting from the December 2005 Biomass to Biofuels Workshop. (July)
  Overview | Print-quality PDF | Fast-download PDF
• Dealing with the Societal Implications of DOE Science: Workshop on Integrating Societal Implications into Science. Chantilly, Virginia. (May 1–2)
  PDF
• Office of Science revises plans for Genomics:GTL facilities. January 10 Funding Call is canceled. (March)
  Press Release
• Review of the Department of Energy’s Genomics: GTL Program, National Research Council of the National Academies (February)
  PDF
• PI Meeting: Joint Genomics:GTL Contractor-Grantee Workshop IV and Metabolic Engineering Working Group Interagency Conference on Metabolic Engineering, North Bethesda, Maryland (February 12–15)
  Overview | Print-quality PDF | Fast-download PDF
• Funding call announced for the GTL Facility for the Production and Characterization of Proteins and Molecular Tags. Genomics:GTL Facility for the Production and Characterization of Proteins and Molecular Tags Funding Opportunity Announced. This Funding Opportunity Announcement requests that the scientific community submit applications for the development of a scientific user facility for the Production and Characterization of Proteins and Molecular Tags that involves the design, construction (construction is used generically here and could include new construction, renovation of existing space, leasing space or other options proposed by the applicants), and research and development related to the design, configuration, and operation of the facility that will serve as a major scientific user facility for the scientific community including the Genomics: GTL program. (Canceled March 26, 2006). (January)
• USDA and DOE to Coordinate Research of Plant and Microbial Genomics: Soybean DNA to be Decoded. The U.S. Departments of Agriculture and Energy announced January 16th they will share resources and coordinate the study of plant and microbial genomics, and the Department of Energy will tackle the sequencing of the soybean genome as the first project resulting from the agreement. (January)
  Press Release

2005

• Microbial Genome Program is completed.
• BER hosts workshop on Breaking the Biological Barriers to Cellulosic Ethanol: Biomass to Biofuels. (December 7–9)
  Report
• Genomics:GTL Roadmap released. (October)
  Press Release | Overview | Print-quality PDF | Fast-download PDF
• Vision: Biotechnology reenergized. How the goals and promise of the Genomes to Life program have energy and environmental applications, Aristides Patrinos, The Scientist (March)
  Website
• PI Meeting: Genomics:GTL Contractor-Grantee Workshop III, Washington, D.C. (February 6–9)
  Overview | PDF

2004

• DOE Genomics:GTL Roadmap Planning Phase 2; Arlington, Virginia. (June 14–16)
• Planning Study I — DOE Genomics:GTL Program Science and Capability Needs for DOE Missions; Washington, D.C. (March 3–4)
• PI Meeting: Genomics:GTL Contractor-Grantee Workshop II, Washington, D.C. (February 29–March 4)
  Overview | PDF
• Program name changed from Genomes to Life to Genomics:GTL (February)

2003

• GTL Researchers Achieve Important Advance in Developing Biological Strategies to Produce Hydrogen, Sequester Carbon Dioxide and Clean Up the Environment, Washington, D.C. (November)
  Press Release | Secretary Abraham’s Remarks
• GTL and Beyond: Data Standards Workshop, San Francisco. (September 10–11)
  Website
• IEEE Bioinformatics Conference Presentations, Stanford, California. (August 11–14)
• Three Genomes to Life Workshops: Data Infrastructure, Modeling and Simulation, and Protein Structure Prediction, Gaithersburg. (July 22–24)
  PDF
• Characterization and Imaging of Molecular Machines Facility Workshop, Atlanta. (July 17–18)
  PDF
• Facility User Interactions Workshop, Gaithersburg. (June 2–3)
• GTL Facility for Production and Characterization of Proteins and Molecular Tags Workshop, Argonne National Laboratory, Chicago. (May 29–30)
  PDF
• Bioinformatics in the GTL Facility for Whole Proteome Analysis, La Jolla, California. (May 12–14)
  PDF
• Energy Department Awards $9 Million for Energy Related Genomic Research. (April)
  Press Release
• “Realizing the Potential of the Genome Revolution: The Genomes to Life Program,” Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, and Aristides Patrinos, Science 300, 290 (2003) (April)
  Website
• GTL Facility for Whole Proteome Analysis, Santa Fe, New Mexico. (April 1–2)
  PDF
• PI Meeting: Genomes to Life Contractor-Grantee Workshop I, Arlington, Virginia. (February 9–12)
  Overview | Print-quality PDF | Fast-download PDF

2002

• Genomes to Life draft facilities strategy and plan submitted to the Biological and Environmental Advisory Committee by the Life Sciences Division of the Biological and Environmental Research program for the December 3–4, 2002 meeting. Revised March 2004. (December)
  PDF
• Genomes to Life Systems Biology Facilities Planning Workshop III, Gaithersburg, Maryland. (October 14–15)
• Genomes to Life Systems Biology Facilities Planning Workshop II, Chicago. (August 16–17)
• Energy Department Awards $103 Million for Post-Genomic Research. (July)
  Press Release
• Genomes to Life Systems Biology Facilities Planning Workshop I, San Francisco. (June 19–20)
  Overview | Print-quality PDF | Fast-download PDF
• Genomes to Life Energy and Climate Change Payoffs poster is exhibited at G-8 Ministers of Energy Summit, Detroit, Michigan. (April 30–May4)
• Computing Strategies Workshop, Oak Ridge, Tennessee. (April 16–19)
• Imaging Workshop for the Genomes to Life Program, Charlotte, North Carolina. (April 16–18)
  PDF
• Mathematics for Genomes to Life Workshop, Gaithersburg, Maryland. (March 18–19)
  PDF | Executive Summary
• Computer Science for Genomes to Life Workshop, Gaithersburg, Maryland. (March 6–7)
  PDF | Executive Summary
• Computing Infrastructure and Networking Workshop for Genomes to Life, Gaithersburg, Maryland. (January 22–23)
  PDF

2001

• Genomes to Life: Technology Assessment for Mass Spectrometry Workshop, Washington D.C. (December 10–11)
  PDF | Executive Summary
• Office of Advanced Scientific Computing Research Advisory Committee Presentation by Gary Johnson. (October)
  PDF
• Genomes to Life Energy and Climate Mission Payoffs Workshop, Chicago. (October 24–25)
• Genomes to Life Science Mission Payoffs Workshop, Washington D.C. (September 9–10)
• Visions for Computational and Systems Biology Workshop for the Genomes to Life Program, Washington D.C. (September 6–7)
  Notes
• First Genomes to Life Computational Biology Workshop was held at the U.S. Department of Energy Headquarters, Germantown, Maryland.
  PDF
• Genomes to Life Workshop on The Role of Biotechnology in Mitigating Greenhouse Gas Concentrations; Arlington, Virginia. Ken Nealson and J. Craig Venter, Workshop Cochairs. (June 23)
• Genomes to Life roadmap document is published in response to recommendations set forth in the 2000 report, “Bringing the Genome to Life.” Revised November 2005. (April)
  PDF
• Initial Working Draft Sequence of the human genome is published in Science and Nature.
  Landmark Human Genome Project Papers
• Genomes to Life Roadmapping Workshop, Germantown, Maryland.

2000

• Genomes to Life Roadmapping Workshop, San Diego, California. (October 29–November 1)
• BERAC publishes “Bringing the Genome to Life” report in response to Martha Krebs’ 1999 charge to define DOE’s potential scientific roles after the Human Genome Project is completed. (August)
• HGP leaders and President Clinton announce the completion of a “working draft” DNA sequence of the human genome. (June)
  Press Release
• DOE researchers announce completion of chromosomes 5, 16, and 19 draft sequence. (April)
  Press Release
• International collaborators publish genome of fruit fly. (March)

1999

• Martha Krebs, then director of DOE’s Office of Science, charges the U.S. Department of Energy’s Biological and Environmental Research Advisory Committee (BERAC) to define DOE’s potential scientific roles after the Human Genome Project is completed. (November 24)
• DOE’s Joint Genome Institute opens the doors on its 60,000 square foot Production Genome Facility in Walnut Creek, California. (October)
  Press Release
• HGP advances completion date for obtaining a draft sequence of the entire human genome from 2001 to 2000.

1998

• Caenorhabditis elegans (roundworm) genome sequence completed.(February)
  Article
• NIH reveal new five-year plan for HGP, predict project completion by 2003. (February)
  Article
• Mycobacterium tuberculosis bacterium sequenced. (July)
  Article
• DOE funds production BAC end-sequencing projects. (February)
  Article

1997

• Escherichia coli (common gut bacteria) genome sequence completed.
  Article
• DOE forms Joint Genome Institute for implementing high-throughput activities at DOE human genome centers, initially in sequencing and functional genomics.
  Article

1996

• Methanococcus jannaschii genome sequenced; confirms existence of third major branch of life on earth.
  Article
• DOE initiates six pilot projects on BAC end sequencing.
  Article
• Saccharomyces cerevisiae (yeast) genome sequence completed by international consortium.
  Article

1995

• First (nonviral) whole genome sequenced (for the bacterium Haemophilus influenzae).
  Article
• Sequence of smallest bacterium, Mycoplasma genitalium, completed; provides a model of the minimum number of genes needed for independent existence.
  Article

1994

• HGP Goal: Genetic-mapping 5-year goal achieved 1 year ahead of schedule.
  Article
• Completion of second-generation DNA clone libraries representing each human chromosome by LLNL and LBNL.
• DOE MGP launched; spin-off of DOE HGP.
  Article
• LLNL whole chromosome paints commercialized.
  Article
• Sequencing by Hybridization (SBH) technologies from ANL commercialized.

1993

• International IMAGE consortium established to coordinate efficient mapping and sequencing of gene-representing cDNAs.
  Article
• DOE and NIH revise 5-year goals [Science 262, 43-46 (Oct. 1, 1993)].
  Article | Science
• ORNL GRAIL sequence-interpretation service provides automatic gene annotations via the Internet.

1992

• Low-resolution genetic linkage map of entire human genome published.
• Guidelines for data release and resource sharing announced by DOE and NIH.
  Article

1991

• Human chromosome mapping data repository, Genome Data Base (GDB) established.

1990

• DOE and NIH present joint 5-year U.S. HGP plan to Congress. The 15-year project formally begins October 1.
  Article
• Projects begun to mark gene sites on chromosome maps as sites of messenger RNA (mRNA) expression.
  Article
• Research and development begun for efficient production of more stable, large-insert bacterial artificial chromosomes (BACs).

1989

• DNA Sequence Tagged Sites (STSs) recommended to correlate diverse types of DNA clones.
  Article

1988

• DOE and NIH sign MOU outlining plans for cooperation on genome research.
  Article
• Telomere (chromosome end) sequence having implications for aging and cancer research is identified at LANL.

1987

• Congressionally chartered DOE advisory committee, Health and Environmental Research Advisory Committee (HERAC), recommends a 15-year, multidisciplinary, scientific, and technological undertaking to map and sequence the human genome. DOE designates multidisciplinary human genome centers.

1986

• Following the Santa Fe conference, DOE Office of Health and Environmental Research [now Office of Biological and Environmental Research (OBER)] announces Human Genome Initiative. With $5.3 million, pilot projects begin at DOE national laboratories to develop critical resources and technologies.

1985

• At DOE Office of Health and Environmental Research, Charles DeLisi and David A. Smith commission the first Santa Fe conference to assess the feasibility of a human genome sequencing initiative.

1984

• DOE OHER (now OBER) and International Commission on Protection Against Environmental Mutagens and Carcinogens (ICPEMC) cosponsor Alta, Utah, conference highlighting the growing role of recombinant DNA technologies. Office of Technology Assessment (OTA) incorporates Alta proceedings into report acknowledging value of human genome reference sequence.
  Article

1983

• LANL and LLNL begin production of DNA clone (cosmid) libraries representing single chromosomes.